Experimental animal models for diabetes and its related complications—a review / 한국실험동물학회지

Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition with high glucose level in the blood plasma resulting from defects in insulin secretion or its action and in some cases both the impairment in secretion and also action of insulin coexist. Historically, animal models have played a critical role in exploring and describing malady pathophysiology and recognizable proof of targets and surveying new remedial specialists and in vivo medicines. In the present study, we reviewed the experimental models employed for diabetes and for its related complications. This paper reviews briefly the broad chemical induction of alloxan and streptozotocin and its mechanisms associated with type 1 and type 2 diabetes. Also we highlighted the different models in other species and other animals.

Experimental animal models for diabetes and its related complications—a review / 한국실험동물학회지

Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition with high glucose level in the blood plasma resulting from defects in insulin secretion or its action and in some cases both the impairment in secretion and also action of insulin coexist. Historically, animal models have played a critical role in exploring and describing malady pathophysiology and recognizable proof of targets and surveying new remedial specialists and in vivo medicines. In the present study, we reviewed the experimental models employed for diabetes and for its related complications. This paper reviews briefly the broad chemical induction of alloxan and streptozotocin and its mechanisms associated with type 1 and type 2 diabetes. Also we highlighted the different models in other species and other animals.

retrospective comparative study of concomitant chemoradiotherapy followed by adjuvant temozolomide versus radiotherapy alone in newly diagnosed Glioblastoma multiforme - an experience at Radium institute, Patna medical college and hospital, India

Introduction: Glioblastoma Multiforme [WHO grade IV glioma] still remains a dreadful diagnosis in oncology with the median survival ranging between 12 to 17 months, despite the recent advances in its management[11,12] It is the most common malignant primary tumour in adults[13]. The standard of care is Maximal Safe Resection followed by Concomitant ChemoRadiotherapy

Methods: During the period 2006 to 2010 at Radium Institute, Patna Medical College and Hospital [PMCH] in India, a study was conducted on 37 newly diagnosed GBM cases in which the control-arm [c-arm] received Conventional Radiotherapy [60Gy/30 number] only whereas the study arm [s-arm] received Concomitant Chemoradiotherapy followed by Adjuvant Temozolomide

Results: The median survival was 15.4 months in the s-arm as compared to 12.4 months in the c-arm. The OS showed a significant improvement with p-value of 0.05 and PFS also showed a benefit with a p-value of 0.005

Conclusion: The results were encouraging with improvement in OS as well as PFS in the s-arm and were at par with the other similar studies conducted in different parts of the world

Lactating adenoma

Lactating adenoma is not a too uncommon tumour of the breast which either occurs de novo or in a pre-existing fibroadenoma affected by pregnancy and lactation hormonal changes. A possible association with invasive carcinoma is discussed which necessitates long term follow up of these patients

Human papilloma virus and cervical neoplasia in Bahrain

A survey of 2,593 cervical smears of the lower female genital tract submitted by the department of Obstetrics and Gynaecology during a period of eighteen months was performed at the Bahrain Defence Force Hospital. Morphological evidence of human papilloma virus [hPV] infection was seen in 1.16% [30 cases]. Out of this 63.33% [19 cases] showed hPV induced dyskaryosis. The majority [63.33%] of hPV infections were seen to occur in the 25-35 years age group. The role of hPV as a sexually transmitted agent and its relationship to neoplasia of the lower female genital tract is discussed